Molecular Cloning of Transferrin Receptor 2
نویسندگان
چکیده
منابع مشابه
Heterotypic interactions between transferrin receptor and transferrin receptor 2.
Cellular iron uptake in most tissues occurs via endocytosis of diferric transferrin (Tf) bound to the transferrin receptor (TfR). Recently, a second transferrin receptor, transferrin receptor 2 (TfR2), has been identified and shown to play a critical role in iron metabolism. TfR2 is capable of Tf-mediated iron uptake and mutations in this gene result in a rare form of hereditary hemochromatosis...
متن کاملMolecular cloning of cDNA for the human interleukin-2 receptor.
Interleukin-2 (IL-2 or T cell growth factor) is a 14,500 daltons glycoprotein critically involved in the development of a normal human immune response [1, 2J. Recently, cDNA for this lymphokine has been isolated and expressed in both prokaryotic and eukaryotic cells [3-5J. Further, the human IL-2 gene has been cloned, sequenced [6], and localized to chromosome 4. As with other polypeptide hormo...
متن کاملRegulation of transferrin receptor 2 protein levels by transferrin.
Transferrin receptor 2 (TfR2) plays a critical role in iron homeostasis because patients carrying disabling mutations in the TFR2 gene suffer from hemochromatosis. In this study, iron-responsive regulation of TfR2 at the protein level was examined in vitro and in vivo. HepG2 cell TfR2 protein levels were up-regulated after exposure to holotransferrin (holoTf) in a time- and dose-responsive mann...
متن کاملDiferric transferrin regulates transferrin receptor 2 protein stability.
Transferrin receptor 2 (TfR2) is a type 2 transmembrane protein expressed in hepatocytes that binds iron-bound transferrin (Tf). Mutations in TfR2 cause one form of hereditary hemochromatosis, a disease in which excessive absorption of dietary iron can lead to liver cirrhosis, diabetes, arthritis, and heart failure. The function of TfR2 in iron homeostasis is unknown. We have studied the regula...
متن کاملTransferrin receptor 2 mediates uptake of transferrin-bound and non-transferrin-bound iron.
BACKGROUND/AIMS Transferrin receptor 2 appears to have dual roles in iron metabolism; one is signalling, the other is iron transport. It is sensitive to high levels of diferric transferrin, which is associated with disorders of iron overload. Also present in these disorders are increased levels of plasma non-transferrin-bound iron. This study sought to clarify the role of transferrin receptor 2...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1999
ISSN: 0021-9258
DOI: 10.1074/jbc.274.30.20826